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Ghrelin is another possible player, since it has been proven to be expressed not only in the gut, but also in a distinct subpopulation of islet cells named ε-cells (231) and, being known to be a stress-induced (232) GLP-1 secretagogue (233, 234), it might play an important role in the intra-islet signaling
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Herein, it is a significant health challenge that leads to a decline in life quality and life expectancy
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